Structural and functional evidence for ephaptic control of Purkinje cell spike timing by networks of molecular layer interneurons
Abstract
Axon collaterals of type 1 molecular layer interneurons (MLI1s) contribute to pinceaux that engulf the initial segments of Purkinje cell (PC) axons and generate extracellular signals that ephaptically inhibit PCs. Here we show that a remarkably large number of MLI1s (~50) contribute to each pinceau, and that this allows networks of synchronously firing MLI1s to use ephaptic signals to control the precise timing of PC firing in vivo.
Links & Resources
Authors
Cite This Paper
A., N., P., L. E., S., O., S., G. C., S., E., A., L. W., A., H. C., G., R. W. (2025). Structural and functional evidence for ephaptic control of Purkinje cell spike timing by networks of molecular layer interneurons. arXiv preprint arXiv:10.64898/2025.12.28.696768.
Norton, A., Lackey, E. P., Ozturk, S., Gaynor, C. S., Ediger, S., Lee, W.-C. A., Hull, C. A., and Regehr, W. G.. "Structural and functional evidence for ephaptic control of Purkinje cell spike timing by networks of molecular layer interneurons." arXiv preprint arXiv:10.64898/2025.12.28.696768 (2025).